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This gene encodes a transcription element that belongs towards the homeobox gene relatives. Genes of this loved ones are highly conserved amongst vertebrates and essential for vertebrate embryonic progress. This gene has been implicated in fetal skin improvement and cutaneous regeneration.

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In mice, an analogous gene was revealed to show temporal and spatial colinearity in the key human body axis with the embryo, but was not expressed while in the secondary axes, which suggests functions in overall body patterning together the axis. This gene along with other HOXB genes type a gene cluster on chromosome seventeen while in the 17q21-22 region.[6]

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